Melius Organics

PFAS-free preparation of fluorochemicals

Heteroatom-CF3 fragments: emerging fluorinated motifs

We have access to a technology to prepare a wide variety of N-, S-, and O-CF3 molecules without the use of PFAS substances. These emerging fluorinated motifs are valuable for tuning lipophilicity, oxidation resistance, and acid-base properties.

Pollution from polyfluorinated alkyl substances (PFAS) is a significant concern for the chemical industry. Our alternative is a method that replaces these materials with convenient alkali fluoride sources to ensure sustainability.

X-CF3 in drug candidates

Some of our examples: