Fluoroalkyl reagents and building blocks
Escaping from flatland: sp3-fluorinated fragments
Fluorinated motifs are valued molecular fragments in medicinal chemistry and crop science. The introduction of sp3 carbons has drawn the attention of synthetic community to prepare new molecules with optimal biological activity and drug-like properties. At Melius Organics we provide a range of reagents capable of introducing these fragments in a late-stage fashion.
We have vast experience in the organic fluorine field.
Contact us for customized solutions.
Fluorine
Influences conformation,
pKa of neighboring groups,
lipophilicity and bioavailability
Rotable bonds, higher flexibility, more conformations, higher solubility
Gaseous regents
Flow chemistry
Photochemistry
Custom synthesis
Sulfinates and sulfonyl halides
Sulfinate salts are a versatile class of reagents in organic synthesis for the preparation of sulfones, sulfonamides, and C-C bond couplings via radical C-H functionalization.
Sulfonyl halides are valuable reagents to prepare sulfonamides and other S(VI) motifs.
We offer both chloride and fluoride forms.
Sulfinates and sulfonyl halides
We offer a range of fluoroalkyl halides, tosylates and difluorocarbene sources to introduce fluoroalkyl units in multiple organic structures.
