Electrophilic thiofluoroalkyl reagents
Thiofluoroalkyl groups, emerging fluorinated motifs
The appendage of fluoroalkyl chains to sulfur results in
unique properties. The marked electronegative nature
of the fluorine atoms, combined with the high electronic
density of the sulfur, allows these fragments to finely
tune lipophilicity and acid-base properties.
Meet our electrophilic reagents
Our advanced saccharin-based electrophilic reagents are specifically engineered for the direct
incorporation of thiofluoroalkyl (SRF) motifs into a wide range of nucleophiles.
- Free-flowing solids
- Bench stable
- Safe & easy to handle
- Mild conditions
Our catalog
Key references
J. Org. Chem. 2022, 87, 10791
Adv. Synth. Catal. 2023, 365, 3438
Angew. Chem. Int. Ed. 2014, 53, 9316
J. Am. Chem. Soc. 2015, 137, 10547